Recombinant Crimean-Congo Hemorrhagic Fever Virus Gc Protein, hFc-Tag
Specification
Related Products
| Cat#: |
CRI-131 |
| Product Name: |
Recombinant Crimean-Congo Hemorrhagic Fever Virus Gc Protein, hFc-Tag |
| Description: |
Recombinant CCHF virus Gc protein (Gc, previously referred to as G1) to meet the increasing need for high quality reagents for research into diagnosis of CCHF, as well as vaccine development. During Crimean Congo Hemarrhagic Fever virus (CCHFV) infection the virus encodes a polyprotein which undergoes a complex proteolytic cascade to generate a number of precursor proteins in addition to two mature structural glycoproteins, Gn and Gc. The mature Gn (37 kDa) and Gc (75 kDa) proteins form the predominant structural glycoprotein components of the virus. |
| Gene: |
Gc |
| Species: |
CCHFV |
| Source: |
HEK293 |
| Synonyms: |
Crimean-Congo Hemorrhagic Fever Virus Gc |
| Formulation: |
PBS, pH7.4. |
| Notes: |
This product is intended for research and manufacturing uses only. It is not a diagnostic device. The user assumes all responsibility for care, custody and control of the material, including its disposal, in accordance with all regulations. |
| Tags: |
Fc |
| Background: |
Crimean Congo hemorrhagic fever (CCHF) virus is a tick-borne enveloped single stranded RNA virus that belongs to the genus Nairovirus and a member of the Bunyaviridae family. CCHF virus causes a hemorrhagic disease in humans with up to 80% case fatality. Although the virus has only caused sporadic disease in the past, the expansion of the range of its vector, the Hyalomma tick, is causing increasing concern that case numbers will continue to rise (Dowall et al., 2017).
Since CCHF was first described in Crimea in 1944, sporadic outbreaks have occurred globally. In 2015, CCHFV was identified by the WHO as an emerging virus which is likely to cause a severe epidemic and which may present a public health emergency. Zoonotic transmission from host animals is the primary route of infection, with concerns this may increase in the next 10-20 years as the timing of religious festivals change. The virus may also be spread effectively by human to human contact, especially in hospital settings. There are also concerns that it may be used as a bioterrorism agent, with evidence that work on this was carried out both in the USSR and in Iraq. |
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
