HIV is a lentivirus of the retroviridae family that can attack and destroy the human immune system, leading to the epidemic of AIDS. Patients usually experience systemic symptoms, including persistent fever, extreme fatigue, and recurrent headaches. Based on genetic and antigenic variation, HIV is divided into two categories: HIV-1 and HIV-2. Compared with HIV-1, HIV-2 has lower toxicity, longer incubation period, and lower rates of sexual transmission and mother-to-child transmission. Since HIV cannot be cured, in vitro diagnostics (IVD) can quickly determine the infection status and prompt patients to seek medical treatment.
Figure 1. The life cycle of HIV. (Masenga S K, et al., 2023)
Main Methods of IVD for Human Immunodeficiency Virus Type 2
Serological testing for HIV-2 antibodies.
Specific immunoblot tests such as western blot (WB).
Specific enzyme immunoassay (EIA), enzyme-linked immunosorbent assay (ELISA), and chemiluminescence immunoassay (CLIA).
Virological detection of HIV-2 DNA or RNA. RT-PCR technology is mainly used to detect HIV-2 RNA.
Gold standard method (test paper detection). By using immunocolloidal gold technology, gold-labeled antibodies bind to HIV-2 antigens in urine to produce a specific color reaction to determine whether it is positive.
Protein chip
Creative BioMart can provide high-quality recombinant HIV-2 gag p26 protein used for IVD, including ELISA, lateral flow assays, western blots, and other immunoassays.
Highlights of Our Products
Completed biological functions and efficient activity.
High sensitivity, high specificity, and high purity.
A wide range of immune tests are available, such as ELISA, lateral flow, WB, and others.
Easy to store and transport, conducive to large-scale production and use of vaccines.
Outstanding success rate and fast development speed.
Our Outstanding Advantages
With a professional R&D team and advanced laboratory facilities, we can conduct a variety of production research and development.
Strict quality control can ensure product stability and reliability.
A complete IVD protein platform can provide customized services to meet different scientific research needs.
High-quality service, high-level experiments, and reliable analysis.
IVD proteins can be used to test for a variety of diseases and conditions, making them valuable tools for diagnosing and monitoring health.
In addition, Creative BioMart also offers a series of viral proteins and protein-related services to provide customers with high-quality, low-cost active recombinant proteins to meet different needs and assist in preclinical drug development.
Creative BioMart offers a series of highly efficient and reliable IVD proteins, providing strong support for medical research and preclinical diagnosis. At the same time, we provide more flexible and personalized protein services that are used in IVD reagents, drug development, biotechnology research and production, and other fields. Please contact us for answers if you are interested in our products or services.
Reference
Masenga S K, Mweene B C, Luwaya E, et al. (2023). HIV–Host Cell Interactions[J]. Cells. 12(10): 1351.
Figure 1. The life cycle of HIV. (Masenga S K, et al., 2023)
