Chagas' disease is a parasitic disease caused by Trypanosoma cruzi and is transmitted by triatomine bugs and kissing bugs. In addition, Trypanosoma cruzi can be transmitted from mother to child or through contaminated needles. Trypanosoma cruzi is a fecal-borne trypanosome that invades the human body through broken skin, mucous membranes, or conjunctiva. Patients develop symptoms such as fever, lymphadenitis, and anemia after infection. Currently, Chagas' disease has become a serious public health problem that requires timely diagnosis and prevention.
Figure 1. ROS and RNS are produced throughout the life cycle of Trypanosoma cruzi. (Mesías A C, et al., 2019)
Main Steps of IVD for Trypanosoma cruzi
Microscopic examination. Thick and thin blood smears were prepared and stained with Giemsa to observe trypanosomes.
Isolation and identification of pathogens. The mice can be inoculated with blood or cultured in a culture medium, and the growth of trypanosomes can be observed subsequently.
Immunological tests. Including indirect fluorescent antibody technology (IFA), indirect hemagglutination test (IHA), immunochromatography test strip method, and enzyme-linked immunosorbent assays (ELISA), which have high sensitivity.
Molecular biology technology. Use DNA probes and PCR technology to detect the variable region and small foreign genes of Trypanosoma cruzi small circle kDNA to obtain diagnostic results.
Peripheral blood picture. In the acute phase of infection, leukocytosis and erythrocyte sedimentation rate are accelerated.
High sensitivity and specificity. The protein can accurately identify and detect specific biomolecules or disease markers.
Highly repeatable.
Easy to store and transport, conducive to large-scale production and use of vaccines.
It is widely used and suitable for downstream immunological experiments.
Outstanding success rate and fast development speed.
Our Outstanding Advantages
We are committed to offering IVD proteins with high performance, reliability, and consistency that exceed industry-leading levels.
The advanced IVD technology platform can provide customized services to meet various scientific research needs, ensuring that customers receive the most appropriate technical services.
A range of quality services, high-level experiments, and reliable analysis are available for the diagnosis of a wide range of diseases and drug development.
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Creative BioMart supports medical research and preclinical diagnostics with a range of highly effective and reliable IVD proteins. In addition, our protein services are versatile and tailored for use in IVD reagents, drug development, biotechnology research, and related fields. Please contact us for more information if you are interested in any of our products or services.
Reference
Mesías A C, Garg N J, Zago M P. (2019). Redox balance keepers and possible cell functions managed by redox homeostasis in Trypanosoma cruzi[J]. Frontiers in Cellular and Infection Microbiology. 9: 435.
Figure 1. ROS and RNS are produced throughout the life cycle of Trypanosoma cruzi. (Mesías A C, et al., 2019)
