Helicobacter pylori (H. pylori) is the only microanaerobic bacterium that can survive in the strong acid environment of the stomach and is mainly transmitted through the oral-oral and fecal-oral routes. After infection, it can cause gastrointestinal symptoms and gastritis. In severe cases, it may even develop into gastric cancer. Currently, the detection and eradication of H. pylori is a hot topic in the prevention and control of digestive system tumors. Therefore, how to accurately diagnose H. pylori infection is a prerequisite for effective prevention and control of gastric cancer. Commonly used in vitro diagnostic (IVD) methods for H. pylori infection are divided into invasive and non-invasive.
Figure 1. The changes and interactional mechanisms of H. pylori and oral microbiota. (Chen X, et al. ,2022)
Main Methods of IVD for Helicobacter pylori
Non-invasive Inspection
Urea breath test (UBT). The main principle is that HP can produce relatively specific urease, which can decompose urea to produce NH3 and CO2.
Stool antigen test (SAT)
Serological testing. These include the protein chip method, western blot (WB), rapid colloidal gold method, enzyme-linked immunosorbent assay (ELISA), and latex-enhanced immunoturbidimetric method, etc.
Molecular Biology Technology
Polymerase chain reaction (PCR)
Quantitative real-time PCR (qPCR)
LAMP
Next-generation sequencing technology (NGS)
Invasive Examination
Endoscopy
Rapid urease test (RUT)
Bacterial culture
Histological sections and histochemical staining microscopy
Completed biological functions and efficient activity.
It is widely used and suitable for downstream immunological experiments.
Easy to store and transport, conducive to large-scale production and use of vaccines.
High sensitivity, high specificity, and high purity.
Outstanding success rate and fast development speed.
Our Outstanding Advantages
IVD proteins can be used to test for a variety of diseases and conditions, making them valuable tools for diagnosing and monitoring health.
Guarantee high performance, high reliability, and high consistency of protein quality, leading the industry.
A complete IVD protein platform can provide customized services to meet different scientific research needs.
High-quality service, high-level experiments, and reliable analysis.
In addition, Creative BioMart also offers a series of viral proteins and protein-related services to provide customers with high-quality, low-cost active recombinant proteins to meet different needs and assist in preclinical drug development.
Creative BioMart offers a series of highly efficient and reliable IVD proteins, providing strong support for medical research and preclinical diagnosis. At the same time, we provide more flexible and personalized protein services that are used in IVD reagents, drug development, biotechnology research and production, and other fields. Please contact us for answers if you are interested in our products or services.
Reference
Chen X, Wang N, Wang J, et al. (2022). The interactions between oral-gut axis microbiota and Helicobacter pylori[J]. Frontiers in Cellular and Infection Microbiology. 12: 914418.
Figure 1. The changes and interactional mechanisms of H. pylori and oral microbiota. (Chen X, et al. ,2022)
