Vaccinia virus (VACV) is a large and complex DNA virus among animal viruses. Studies have found that VACV can be used as a live virus vaccine against smallpox. Currently, VACV has been used by scientific researchers as a tool to deliver genes into biological tissues in gene therapy and genetic engineering. In addition, VACV is used in recombinant vaccines as a vector to express foreign genes within the host to generate an immune response. VACV infection is usually very mild and usually causes no symptoms in healthy individuals, although it may cause rash and fever.
Figure 1. Anti-viral DNA sensing and its antagonism by VACV. (El-Jesr M, et al., 2020)
Main Methods of IVD for Vaccinia Virus
Antigen testing. VACV has specific antigens, and viral antigens are detected from infected cells or virus particles to determine the infection status.
Serological testing. Vaccinia virus infection can be indirectly diagnosed by collecting serum samples from infected people and testing for antibodies. The main methods include immunofluorescence, ELISA, WB, etc.
Nucleic acid amplification testing. The DNA sequence of VACV in the sample is mainly detected by PCR.
Virus isolation and culture. VACV was inoculated into sensitive cell lines, the pathological characteristics of the cells were observed, and the virus was isolated and identified.
Creative BioMart can provide a range of vaccinia viruses for IVD, including ELISA, lateral flow assays, western blots, and other immunoassays.
In addition to the above products, there are many VACVs for you to choose from. You can click on the product list to view them.
Highlights of Our Products
High sensitivity, high specificity, and high purity.
Outstanding success rate and fast development speed.
Completed biological functions and efficient activity.
A wide range of immune tests are available, such as ELISA, lateral flow, WB, and others.
Easy to store and transport, conducive to large-scale production and use of vaccines.
Our Outstanding Advantages
IVD proteins can be used to test for a variety of diseases and conditions, making them valuable tools for diagnosing and monitoring health.
Guarantee high performance, high reliability, and high consistency of protein quality, leading the industry.
A complete IVD protein platform can provide customized services to meet different scientific research needs.
High-quality service, high-level experiments, and reliable analysis.
In addition, Creative BioMart also offers a series of viral proteins and protein-related services to provide customers with high-quality, low-cost active recombinant proteins to meet different needs and assist in preclinical drug development.
Creative BioMart offers a series of highly efficient and reliable IVD proteins, providing strong support for medical research and preclinical diagnosis. At the same time, we provide more flexible and personalized protein services that are used in IVD reagents, drug development, biotechnology research and production, and other fields. Please contact us for answers if you are interested in our products or services.
Reference
El-Jesr M, Teir M, Maluquer de Motes C. (2020). Vaccinia virus activation and antagonism of cytosolic DNA sensing[J]. Frontiers in Immunology. 11: 568412.
Figure 1. Anti-viral DNA sensing and its antagonism by VACV. (El-Jesr M, et al., 2020)
