Apple is a fruit rich in nutrients, dietary fiber, and water content, but some people will develop allergic symptoms after eating it. For patients who are allergic to apples, their immune systems do not recognize proteins such as Mal d 1, Mal d 2, and Mal d 3. Such allergenic proteins enter the body bind to IgE antibodies and promote the release of histamine, leading to diarrhea and vomiting. In addition, apples contain a large amount of fruit acids and vitamins, which combine with the tissues in the human body to form different chemicals to further stimulate the immune system and induce allergic reactions.
Main Steps of IVD for Apple Allergy
Skin Prick Test
Prick or inject apple extract into the skin and observe the skin's reaction to determine the allergic status.
Serum IgE Antibody Test
In serological testing, apple allergy can usually be diagnosed if the patient has high levels of specific IgE antibodies.
Oral Food Challenge (OFC)
Eat apples or related products and observe whether the patient has an allergic reaction to determine allergy.
Creative BioMart provides high-quality recombinant Mal d 3 apple allergen protein used for IVD, including ELISA, lateral flow assay, western blot, and other immunoassays.
Highlights of Our Products
Higher safety and repeatability. Genetic engineering technology allows it to be produced without non-specific allergens.
High purity. No contamination from exogenous toxic substances and pathogenic microorganisms.
High specificity. The molecular structure and biological activity of recombinant allergens are similar to natural allergens and can effectively stimulate immune responses in allergic patients.
Easy to scale up production.
Our Outstanding Advantages
A rich variety of IVD products to meet the different needs of customers and provide customers with comprehensive scientific research support.
Strong technical team, advanced scientific research equipment, and technology that can provide high-quality services.
Focus on delivering high-quality services to customers, providing timely and precise IVD protein services.
In addition, Creative BioMart also offers a series of allergen proteins and protein-related services to provide customers with high-quality, low-cost active recombinant proteins to meet different needs and assist in preclinical drug development.
Creative BioMart has a wide range of highly effective and reliable IVD proteins for use in medical research and preclinical diagnostics. We also offer custom protein services to meet the diverse needs of IVD reagents, drug discovery, biotechnology research, and other related sectors, providing flexible solutions to meet individual requirements. Please contact us for more details if you are interested in our products or services.
Reference
Oberhuber C, Ma Y, Marsh J, et al. (2008). Purification and characterisation of relevant natural and recombinant apple allergens[J]. Molecular nutrition & food research. 52(S2): S208-S219.
