Leptospirosis is an acute animal-borne infectious disease caused by pathogenic Leptospira. Rodents and pigs are the main sources of infection, and infection occurs through skin and mucous membrane contact with infected water containing leptospira. After Leptospira invades the human body, it reproduces through lymphatic vessels or directly enters the human bloodstream to produce toxins, forming Leptospira sepsis, accompanied by damage and dysfunction of various organs. Leptospira infection can be diagnosed clinically through microscopy, culture, serological, and immunological tests.
Figure 1. Zoonotic cycle of leptospirosis, susceptibility of various accidental hosts, and transmission modes. (Bonhomme D, et al., 2022)
Main Steps of IVD for Pathogenic Leptospira
Serological tests. The microagglutination test (MAT) detects the presence of specific antibodies in the serum, and the diagnosis is confirmed by a dramatic increase in titer. Enzyme-linked immunosorbent assay (ELISA) measures Leptospira IgM antibodies in serum and cerebrospinal fluid, and its specificity and sensitivity are higher than MAT.
Blood culture. The patient's blood sample is inoculated into culture media for subsequent diagnosis.
Molecular biology tests. PCR technology can be used to specifically, sensitively, and rapidly detect Leptospira DNA in whole blood, serum cerebrospinal fluid, or urine.
Complement fixation tests and indirect immunofluorescence tests.
Completed biological functions and efficient activity.
Versatile and suitable for downstream immunology experiments, including ELISA and Western blotting.
High sensitivity, high specificity, and high purity.
Easy to store and transport, conducive to large-scale production and use of vaccines.
A high success rate and rapid development that surpasses peers in the IVD field.
Our Outstanding Advantages
High-quality service, high-level experiments, and reliable analysis can ensure the success of the experiment.
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Reference
Bonhomme D, Werts C. (2022). Host and species-specificities of pattern recognition receptors upon infection with Leptospira interrogans[J]. Frontiers in Cellular and Infection Microbiology. 12: 932137.
Figure 1. Zoonotic cycle of leptospirosis, susceptibility of various accidental hosts, and transmission modes. (Bonhomme D, et al., 2022)
