Filarial worms belong to the superfamily Filarioidea and are transmitted by different species of mosquitoes. They are a general term for a class of parasitic nematodes that parasitize humans and other vertebrates. Filariasis is a parasitic disease caused by filarial worms parasitizing in lymphoid tissue, subcutaneous tissue, or serosal cavity. Filariasis mainly manifests as lymphangitis and lymphadenitis in the early stage, while in the late stage, it will produce a series of symptoms, including lymphedema, hydrocele, and chyluria. These diseases negatively impact human and animal health, so the prevention and control of filarial animals are very important.
Figure 1. Filarial life-cycle. (Ehrens A, et al., 2022)
Main Steps of IVD for Filariodidea
Serological tests. The patient's peripheral blood was collected for smear examination. For chyluria or lymphatic effusion, take a sediment smear after centrifugation.
Antibody testing. Antibodies were detected using the indirect fluorescent antibody test (IFAT) for adult worm frozen section antigens, the immunoenzyme staining test (IEST) for adult worm frozen sections, and the soluble antigen enzyme-linked immunosorbent assay (ELISA) for filarial worms.
Antigen testing. Filarial antigens were detected by the ELISA double antibody method and spot ELISA using monoclonal antibodies against filarial antigens.
A wide range of immune tests are available, such as ELISA, lateral flow, WB, and others.
High sensitivity, high specificity, and high purity.
Strong stability. Drying, freezing, or lyophilizing maintains its properties and functionality.
The high success rate is conducive to the development of experiments.
Our Outstanding Advantages
The IVD proteins we provide have characteristics such as specificity, sensitivity, high efficiency, reproducibility, stability, and safety, which are beneficial to preclinical diagnosis and medical research.
A complete IVD protein platform can provide customized services to meet different scientific research needs.
High-quality service, high-level experiments, and reliable analysis.
IVD proteins can be used to test for a variety of diseases and conditions, making them valuable tools for diagnosing and monitoring health.
We ensure that the high performance, high reliability, and high consistency of product quality can meet research standards.
In addition, Creative BioMart also offers a series of viral proteins and protein-related services to provide customers with high-quality, low-cost active recombinant proteins to meet different needs and assist in preclinical drug development.
Creative BioMart is committed to offering a wide range of high-quality IVD proteins to provide strong support for life science research and preclinical diagnosis. In the fields of drug research and development, biotechnology research, and IVD reagent production, our customized protein services can flexibly meet the needs of different customers. Please contact us for answers if you are interested in our products or services.
Reference
Ehrens A, Hoerauf A, Hübner M P. (2022). Eosinophils in filarial infections: Inducers of protection or pathology?[J]. Frontiers in Immunology. 13: 983812.
Figure 1. Filarial life-cycle. (Ehrens A, et al., 2022)
