Genital herpes is a sexually transmitted disease caused by herpes simplex virus type 2 (HSV-2). It can be transmitted through sexual contact or perinatal infection of newborns in the uterus or birth canal and has a particularly serious impact on women. After the HSV-2 virus infects the human body, it will lie dormant in the skin, mucous membranes, and nervous tissue. During a period of reduced immunity, latent viruses can become active and cause recurrent infections. An individual infected with HSV-2 is also more likely to be infected with and transmit immunodeficiency virus (HIV).
Figure 1. Anti-HSV immune response when HSV enters the female human body, epithelial cells recognize HSV in a PRR-dependent or PRR-independent manner. (Kim H C, et al., 2020)
Main Methods of IVD for Herpes Simplex Virus Type 2
Serological testing. Infection can be determined by detecting HSV-2 antibodies in serum.
PCR test. Through the use of PCR reactions, the genetic material of the HSV-2 can be detected in specimens collected from lesions or body fluids, such as cerebrospinal fluid.
Perform in vitro cell culture. The collected specimens are inoculated into specific cells, and the presence of virus proliferation is observed through cell culture to determine whether the virus is infected with HSV-2.
Cellular immunohistochemistry, immunofluorescence technology, and in situ hybridization technology.
Creative BioMart can provide high-quality recombinant HSV-2 glycoprotein G used for IVD, including ELISA, lateral flow assays, western blots, and other immunoassays.
Highlights of Our Products
High purity and uniformity. The protein purity is above 90% and verified by SDS-PAGE.
Completed biological functions and efficient activity.
A wide range of immune tests are available, such as ELISA, lateral flow, WB, and others.
Easy to store and transport, conducive to large-scale production and use of vaccines.
High batch-to-batch consistency and low variability.
Our Outstanding Advantages
Viral proteins are continuously improved and come in a wide variety to meet different research and development needs.
With a professional R&D team and advanced laboratory facilities, we can conduct a variety of production research and development.
A complete IVD protein platform can provide customized services to meet different scientific research needs.
High-quality service, high-level experiments, and reliable analysis.
IVD proteins can be used to test for a variety of diseases and conditions, making them valuable tools for diagnosing and monitoring health.
In addition, Creative BioMart also offers a series of viral proteins and protein-related services to provide customers with high-quality, low-cost active recombinant proteins to meet different needs and assist in preclinical drug development.
Creative BioMart offers a series of highly efficient and reliable IVD proteins, providing strong support for medical research and preclinical diagnosis. At the same time, we provide more flexible and personalized protein services that are used in IVD reagents, drug development, biotechnology research and production, and other fields. Please contact us for answers if you are interested in our products or services.
Reference
Kim H C, Lee H K. (2020). Vaccines against genital herpes: Where are we?[J]. Vaccines. 8(3): 420.
Figure 1. Anti-HSV immune response when HSV enters the female human body, epithelial cells recognize HSV in a PRR-dependent or PRR-independent manner. (Kim H C, et al., 2020)
