Chikungunya fever is an arboviral disease caused by chikungunya virus (CHIKV) and transmitted by Aedes mosquitoes. It is common in tropical and subtropical regions. Symptoms of chikungunya mainly include fever and headache, often accompanied by joint pain and lower back pain. In addition, CHIKV may cause meningoencephalitis and other central nervous system diseases in newborns. Currently, laboratories can perform in vitro diagnostics (IVD) of CHIKV infection by detecting virus-specific IgM/IgG antibodies and viral RNA.
Figure 1. Successive steps of chikungunya virus infection in humans, based on human clinical data and animal experiments. (Couderc T, et al., 2015)
Main Steps of IVD for Chikungunya
Antigen and antibody testing. Serum samples from patients in the acute phase of the disease were collected and tested using ELISA, immunochromatography, and immunofluorescence antibody assay (IFA).
Nucleic acid amplification testing. Blood samples from patients can be collected and RT-PCR and other methods can be used to detect the nucleic acid of the virus to diagnose CHIKV infection.
Virus isolation and culture. Samples such as serum, blood cells, or saliva are collected from patients in the acute stage of illness, inoculated into sensitive cells, and the virus is isolated and cultured.
Creative BioMart provides high-quality recombinant Chikungunya capsid protein used for IVD, including ELISA, lateral flow assays, western blots, and other immunoassays.
Highlights of Our Products
High sensitivity, high specificity, and high purity.
It is widely used and suitable for downstream immunological experiments.
Easy to store and transport, conducive to large-scale production and use of vaccines.
Outstanding success rate and fast development speed.
Our Outstanding Advantages
Viral proteins are continuously improved and come in a wide variety to meet different research and development needs.
With a professional R&D team and advanced laboratory facilities, we can conduct a variety of production research and development.
A complete IVD protein platform can provide customized services to meet different scientific research needs.
High-quality service, high-level experiments, and reliable analysis.
IVD proteins can be used to test for a variety of diseases and conditions, making them valuable tools for diagnosing and monitoring health.
In addition, Creative BioMart also offers a series of viral proteins and protein-related services to provide customers with high-quality, low-cost active recombinant proteins to meet different needs and assist in preclinical drug development.
Creative BioMart offers a series of highly efficient and reliable IVD proteins, providing strong support for medical research and preclinical diagnosis. At the same time, we provide more flexible and personalized protein services that are used in IVD reagents, drug development, biotechnology research and production, and other fields. Please contact us for answers if you are interested in our products or services.
Reference
Couderc T, Lecuit M. (2015). Chikungunya virus pathogenesis: From bedside to bench[J]. Antiviral research. 121: 120-131.
Figure 1. Successive steps of chikungunya virus infection in humans, based on human clinical data and animal experiments. (Couderc T, et al., 2015)
