HSV-1 is a common viral infection that causes mucosal lesions such as cold sores in humans. Infection usually occurs in infancy, and the virus can remain dormant for years, sometimes even reactivating repeatedly, causing recurrent disease. In addition, HSV-1 is a neuroinvasive pathogen, that usually leads to excessive accumulation of Aβ42 in the neurons of infected individuals, increased intracellular Tau protein levels, and rare encephalitis. After invading the host's peripheral nervous system, the virus may increase the risk of Alzheimer's disease (AD) in older adults.
Figure 1. Model of HSV1-induced neuroinflammation in the PNS as a trigger for Alzheimer's disease (AD). (Laval K, et al., 2021)
In vitro diagnostic (IVD) methods for HSV-1 mainly rely on biochemistry and molecular biology techniques.
Main Methods of IVD for Herpes Simplex Virus Type 1
Utilize PCR technology for HSV-1 genetic testing. It is highly sensitive and can produce detection reports within a few hours.
Serological testing. It mainly detects specific immunoblotting of glycoprotein G antibodies and uses Western blot to detect antibodies to various HSV-1 proteins.
Perform in vitro cell culture. Sampling the lesion or collecting body fluid specimens such as cerebrospinal fluid to inoculate cells and culture and isolate the virus to make a diagnosis.
Cellular immunohistochemistry and immunofluorescence techniques are used to detect herpes simplex virus antigen proteins, or in situ hybridization technology is used to detect its genetic components to further classify HSV-1.
Creative BioMart can provide high-quality recombinant HSV-1 glycoprotein G used for IVD, including ELISA, lateral flow assays, western blots, and other immunoassays.
Highlights of Our Products
Completed biological functions and efficient activity.
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A wide range of immune tests are available, such as ELISA, lateral flow, WB, and others.
Easy to store and transport, conducive to large-scale production and use of vaccines.
Outstanding success rate and fast development speed.
Our Outstanding Advantages
With a professional R&D team and advanced laboratory facilities, we can conduct a variety of production research and development.
Strict quality control can ensure product stability and reliability.
A complete IVD protein platform can provide customized services to meet different scientific research needs.
High-quality service, high-level experiments, and reliable analysis.
IVD proteins can be used to test for a variety of diseases and conditions, making them valuable tools for diagnosing and monitoring health.
In addition, Creative BioMart also offers a series of viral proteins and protein-related services to provide customers with high-quality, low-cost active recombinant proteins to meet different needs and assist in preclinical drug development.
Creative BioMart offers a series of highly efficient and reliable IVD proteins, providing strong support for medical research and preclinical diagnosis. At the same time, we provide more flexible and personalized protein services that are used in IVD reagents, drug development, biotechnology research and production, and other fields. Please contact us for answers if you are interested in our products or services.
Reference
Laval K, Enquist L W. (2021). The potential role of herpes simplex virus type 1 and neuroinflammation in the pathogenesis of Alzheimer's disease[J]. Frontiers in Neurology. 12: 658695.
Figure 1. Model of HSV1-induced neuroinflammation in the PNS as a trigger for Alzheimer's disease (AD). (Laval K, et al., 2021)
