Like allergies to pollen, dust mites, and seafood, wheat allergy is also a type I allergic reaction mediated by IgE. Currently, the World Health Organization (WHO) has provided 13 wheat allergens, including Tri a 14, Tri a 18, Tri a 19, etc. The body's immune system treats specific proteins in wheat as foreign matter, activates phagocytes, releases histamine and prostaglandins, dilates capillaries, and increases vascular permeability. Symptoms of allergy patients generally include eczema, itchy skin, asthma, and even shock in severe cases. Due to its simplicity, non-invasiveness, and low cost, serological antibody testing has been promoted primarily for wheat allergy diagnosis and screening.
Main Steps of IVD for Wheat Allergy
Immunological Test
By detecting IgE levels in the serum of allergic patients, including total IgE determination and specific IgE determination. These assays can detect a patient's specific immune response to wheat.
Skin Prick and Intradermal Test
These tests determine wheat allergy by piercing or injecting the wheat extract into the skin and observing the skin's reaction.
Biosensor Technology
This technology can be used to detect the electrical signal when wheat allergen binds to IgE antibodies, thereby quickly and accurately detecting whether a patient is allergic to wheat.
Creative BioMart provides high-quality recombinant wheat allergen proteins used for IVD, including ELISA, lateral flow assay, western blot, and other immunoassays.
High purity and specificity, no non-specific allergen contamination.
Strong controllability. Industrialized production makes it easier to carry out quality control to ensure product uniformity and stability.
Stable and easy to store and transport. The protein structure is stable and not easily affected by environmental factors, ensuring product uniformity.
Higher safety and repeatability.
Our Outstanding Advantages
Our IVD proteins are capable of identifying a broad variety of allergies, making them highly valuable tools in the monitoring and diagnosis of health.
Our company has a strong technical team, advanced scientific research equipment, and technology that can provide high-quality services.
A rich variety of IVD products to meet the different needs of customers and provide customers with comprehensive scientific research support.
In addition, Creative BioMart also offers a series of allergen proteins and protein-related services to provide customers with high-quality, low-cost active recombinant proteins to meet different needs and assist in preclinical drug development.
Creative BioMart can offer a variety of IVD proteins for use in a variety of IVD platforms, such as immunoassays, biosensors, genetic testing, etc. At the same time, we provide more flexible and personalized protein services that are used in IVD reagents, drug development, biotechnology research and production, and other fields. Contact us to learn more about our comprehensive range of products and services.
Reference
Pastorello E A, Toscano A, Scibilia G, et al. (2022). Clinical features of wheat allergy are significantly different between Tri a 14 sensitized patients and Tri a 19 sensitized ones[J]. International Archives of Allergy and Immunology. 183(6): 591-599.
