Milk is a nutritious food, but some people experience allergic reactions after drinking milk. 80% of milk protein is made up of casein, while the remaining 20% comprises whey protein, which is considered the main trigger for milk allergy. Clinical allergen research has found that β-lactoglobulin and a-casein in milk are the most common allergens, which can cause symptoms such as rash, vomiting, diarrhea, and wheezing. Infants and young children have the highest rate of allergy to milk protein due to their immature intestinal mucosal barrier and immune system. Currently, blood tests for specific IgE can be used to assist in the diagnosis of IgE-related milk protein allergy.
Main Steps of IVD for Caw Milk Allergy
IgE Antibody Test
Through the fluorescent enzyme immunoassay, the patient's serum sample is taken and the total amount of specific IgE in the patient's sample is checked to determine the allergy.
Skin Prick Test
Drop a small amount of highly purified allergen solution on the patient's forearm skin, then use a puncture needle to gently penetrate the skin surface, and finally wait 15 to 20 minutes to observe the skin condition. If there is an allergic reaction to the allergen, symptoms such as local wheals, erythema, and itching will occur.
Oral Food Challenge (OFC)
Implement gradually from low concentration to high concentration.
Tryptase Test
Venous blood collection or 24-hour urine collection can be used to confirm whether the patient is allergic to milk.
Creative BioMart provides high-quality recombinant caw milk allergen protein used for IVD, including ELISA, lateral flow assay, western blot, and other immunoassays.
High sensitivity and specificity. The protein can accurately identify and detect allergens.
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Provide customers with timely and accurate IVD-related services, and ensure that customers can get the best scientific research experience.
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Creative BioMart supports medical research and preclinical diagnostics with a range of highly effective and reliable IVD proteins. In addition to IVD proteins, we offer a range of protein services that find significant applications in areas encompassing reagent production, drug R&D, biotechnology research, and other related domains. If you are interested in our products or services, please contact us for further information.
Reference
Bernard H, Negroni L, Chatel J M, et al. (2000). Molecular basis of IgE cross-reactivity between human β-casein and bovine β-casein, a major allergen of milk[J]. Molecular Immunology. 37(3-4): 161-167.
