Native Respiratory Syncytial Virus A Lysate
Specification
Related Products
| Cat#: |
RES-553 |
| Product Name: |
Native Respiratory Syncytial Virus A Lysate |
| Description: |
Respiratory Syncytial Virus A Lysate is purified from Vero cells using sucrose density gradient ultracentrifugation, disrupted in the presence of detergent and heat inactivated. Viral lysates can be utilized as an antigen, as a source for the purification of viral proteins, or for the detection of viral antibodies. |
| Gene: |
Respiratory Syncytial Virus A Lysate |
| Species: |
Respiratory Syncytial Virus |
| Synonyms: |
Respiratory Syncytial Virus A Lysate |
| Notes: |
This product is intended for research and manufacturing uses only. It is not a diagnostic device. The user assumes all responsibility for care, custody and control of the material, including its disposal, in accordance with all regulations. |
| Applications: |
Appropriate for the development of immunoassays, Western blotting, dot blotting and other protein-based assays. |
| Background: |
Respiratory syncytial virus (RSV, also known as human orthopneumovirus) is a negative-sense, single-stranded RNA virus belonging to the Pneumoviridae family. RSV is a medium-sized virus (120-200nm) and includes a viral envelope. The RSV genome is approximately 15kb in length and encodes 10 genes and 11 proteins. From 3-5', the genome encodes the non-structural proteins 1 and 2 (NS1, NS2), Nucleoprotein (N), Phosphoprotein (P), Matrix protein (M), Small hydrophobic protein (SH), Glycoprotein (G), Fusion protein (F), Matrix protein 2 (M2), and Large protein (L) (Borchers et al. 2013). There is only one RSV serotype, which includes the major antigenic subgroups A and B (Gilca et al., 2006). In temperate climates, RSV transmission shows a distinct seasonality with typical onset in late autumn to early winter, and a peak between mid-December and early February. In the USA, 60% of infants are infected during their first HRSV season It is generally believed that most children will have experienced at least one RSV infection by the age of 2 years (Borchers et al. 2013). Of those infected, 2–3% will develop bronchiolitis and require hospitalisation. The resulting natural immunity is protective but wanes over time, such that people can be infected multiple times. Possible co-infection of respiratory syncytial virus and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been reported (Burstein et al., 2020). |
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
